University of Pittsburgh · VA Pittsburgh

Soumik Purkayastha

Assistant Professor, Department of Biostatistics & Health Data Science, University of Pittsburgh School of Public Health

Mathematical Statistician, Center for Healthcare Evaluation, Research, and Promotion (CHERP), VA Pittsburgh Healthcare System

I develop statistical and AI methods for discovering structure, quantifying association, and extracting safety-relevant signal from complex health data. My methodological work spans weighted Bayesian network learning, information-theoretic association estimation, and federated inference. With colleagues at CHERP, I co-develop clinical AI for medical device safety surveillance and serve as statistician/co-investigator on health services and clinical research projects, with a focus on Veterans.

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Statistical methods for complex biomedical data

I develop graphical models for learning causal structure and quantifying directional association under realistic biomedical data conditions — survey weighting, mixed-typed variables, ordinal outcomes, and beyond rigid parametric assumptions. Recent work spans copula-based mutual information, generative exposure models and graphical models for learning network structure, and federated learning.

copula models · density estimation · federated learning · graphical models · robust inference · structure learning
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AI models for medical device safety

With colleagues at VA Pittsburgh, I co-develop AI models for adverse-event surveillance. Our current focus is insulin pumps and continuous glucose monitors — the second-largest source of medical-device-related injuries reported to the FDA. Active extensions integrate extracted risk signal into provider-facing registries and Veteran-facing safety education materials.

adverse-event surveillance · deep learning · foundation models · trustworthy AI
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Health services research (HSR)

I serve as the statistician on a portfolio of health services and clinical research projects, most of them at VA Pittsburgh's Center for Healthcare Evaluation, Research, and Promotion (CHERP). Active threads include alcohol use disorder treatment, guideline-directed therapy for heart failure, social risks among sexual and gender minority Veterans, HPV vaccination, and organ transplantation.

causal inference · micro- and macro-simulation models · pharmacoepidemiology · survey design ·

Working on federated generalized estimating equations for distributed health data; survey-weighted ordinal Bayesian network learning for Veteran mental-health surveys; and the impact of declining drug-overdose mortality on deceased-donor organ transplantation.

Fast and consistent copula-based nonparametric estimator of mutual information.
R · Github
Bivariate causal discovery via the generative exposure model.
Python · Github
Covariate-adjusted bivariate causal discovery via the generative exposure model.
R · Github
Survey-weighted, covariate-adjusted ordinal Bayesian network learning.
R · in development
Federated generalized estimating equations for multicenter longitudinal data.
R · in development
Extended SEIR model with false-negative correction and symptom-based testing.
R · CRAN
Oct 2026
Collaborative paper on a yoga intervention for idiopathic pulmonary fibrosis (YES-IPF) published in Respiratory Medicine.
Sep 2026
Collaborative paper on living donor liver transplant for intrahepatic cholangiocarcinoma published in American Journal of Transplantation.
Jul 2026
Collaborative paper on surgical management trends in oropharyngeal cancer accepted at Head & Neck.
June 2026
Trainee Feier Chang won the 2026 WNAR Most Outstanding Student Presentation Award.
May 2026
Work on drug overdose mortality decline in the United States accepted at American Journal of Transplantation.
Apr 2026
Work on medications for alcohol use disorder among hospitalized Veterans accepted at Annals of Internal Medicine.
Feb 2026
Paper on minimum Bregman divergence inference accepted at Mathematics.
Jan 2026
Paper on quantification and cross-fitting inference under generative exposure mapping models accepted at Statistica Sinica.
Dec 2025
Work on social risks and social needs concordance among Veterans accepted at JAMA Network Open.